NFL Point Spreads For Week 3 - Week Three NFL Football Point Spread - NFL Spreads 9/21 . Check back next week for NFL point spreads for week 4 games. Week 2 kicks off with a Thursday Night Football game between the Houston Texans and Cincinnati Bengals. NFL Week 2 schedule: Point spreads, picks, predictions for every game . Detroit Lions at New York Giants (- 4). NFL Week 3 early odds: Browns favored in a road game for first time in three Here's an early look at the lines for all NFL games being played in Week 3 the Browns opened as a 4 - point favorite for a game in Jacksonville.
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