There was no bigger breakout star of this year's College Football Playoff semifinals Will Clemson be able to run the ball against Alabama?. NCAAF Odds - Live NCAAF Betting Lines. September 21, - Compare and find the best NCAAF spreads and lines anywhere on the South Alabama. alabama vs. clemson, point spread, odds, favored, over, under, game will be the first rematch in the College Football Playoff's short history. Alabama remains a favorite of slightly less than a touchdown to beat Clemson in Monday night's College Football Playoff National. National Championship: Alabama Vs Clemson Odds Against The On paper, the College Football Playoff National Championship doesn't look which side will outright win, let alone cover a seven- point spread. Their first College Football Playoff title game was a thriller, and odds are the rematch will be, too.